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Aspergillus infections cause a spectrum of pulmonary diseases depending on the immune status of the host. We report a rare case of a young, immunocompetent, patient who developed Aspergillus tracheobronchitis. Owing to primary resistance to itraconazole, the disease progressed to aspergilloma despite treatment. The condition was successfully treated with(More)
BACKGROUND While autonomic neuropathy has been reported in chronically hypoxaemic patients of chronic obstructive pulmonary disease (COPD), whether it also occurs in patients with milder disease and in those without chronic hypoxaemia has not been explored. METHODOLOGY Lung function measurements including spirometry and transfer factor for carbon(More)
CONTEXT CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to influence the cytokine profile and subsequent immunoglobulin E production in response to antigen/allergen contact in allergic phenotypes. AIMS The present study was to investigate genetic polymorphism in CD14(More)
  • Sajal De
  • Indian journal of physiology and pharmacology
  • 2012
Body mass index (BMI) is one of the important parameter to assess functional status of patients with Chronic Obstructive Pulmonary Disease (COPD). The aim of present study was to assess the prevalence of underweight among clinically stable COPD patients and relationship of BMI with increasing severity of COPD. COPD was defined as a subject who had(More)
  • Sajal De
  • The Indian journal of chest diseases & allied…
  • 2011
BACKGROUND Psychological impairment is a significant co-morbid condition of chronic obstructive pulmonary disease (COPD). No studies from India have been conducted to assess the prevalence of depression in COPD. METHODS We investigated the prevalence of depression in 100 consecutive stable COPD patients during their routine outpatient department visits.(More)
OBJECTIVE Prospective evaluation of inhouse developed SEVA TB ELISA using cocktail of Mycobacterial antigens ES-31 and EST-6 (containing ES-38 and ES-41) and their specific antibodies in the diagnosis of Tuberculous pleural effusion was done in a tertiary care hospital. METHODS Detection of circulating free and immune-complexed (IC) antigens and antibody(More)
  • Sajal De
  • Journal of bronchology & interventional…
  • 2009
BACKGROUND Bronchoscopy is usually performed under sedation to improve patient comfort and willingness to accept a repeat procedure. Bronchoscopy with a low dose of sedation does not necessarily improve patient comfort, and overt sedation may be dangerous for those with preexisting lung diseases. OBJECTIVES The aim of this study was to evaluate the visual(More)
  • Sajal De
  • The Indian journal of chest diseases & allied…
  • 2011
BACKGROUND Lidocaine is commonly used for topical anaesthesia during fibreoptic bronchoscopy (FOB) and it can cause methaemoglobinemia. The present study was undertaken to evaluate the severity of post-bronchoscopy methaemoglobinemia while using lidocaine as a topical anaesthetic agent. METHODS We prospectively studied consecutive adult patients who(More)
  • Sajal De
  • The Indian journal of medical research
  • 2012
BACKGROUND & OBJECTIVES A large numbers of subjects were exposed to the aerosol of methyl isocyanate (MIC) during Bhopal gas disaster and lung was one of the most commonly affected organs. The aim of the present study was to analyze retrospectively the lung function abnormalities among the surviving MIC exposed population (gas victims) and to compare it(More)