Saima Kulsoom

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Epilepsy is a common neurological disorder throughout the world which is characterized by recurrent unprovoked epileptic seizures. A need exists for the development of new antiseizure drugs with improved efficacy and tolerability, as several of the currently available antiepileptic drugs (AEDs) have been associated with severe side effects. A ligand based(More)
Butyrylcholinesterase present in the serum, heart, lung, intestine, liver, and kidney plays an important role in the metabolism of ester containing compounds. Several neuronal groups solely show the activity of BChE in the human brain, such as in the inhibition or the absence of AChE, BChE can replace AChE in the degradation of acetylcholine ACh. Such(More)
To identify the most active antiepileptic compound, we undertook a structure-based design approach that used three-dimensional structural model of the γ-aminobutyrate aminotransferase and GABA-AT protein, and molecular docking simulations of newer agents, 4-bromophenyl-substituted aryl semicarbazones, sulphonamide derivative-hydrophobic domain,(More)
Microtubules have always remained a mainstay in the discussion of anti-cancer drugs. Research is being carried out since over a decade on the microtubule-binding agents. The already present drugs have acquired clinical disadvantages or limitations, most importantly, the acquired resistance. Microtubule-stabilizing anti-mitotic agents (MSAAs) has proved(More)
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