Sailesh K. Mishra

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Clonidine added to local anaesthetics prolongs the duration of anaesthesia and analgesia of peripheral, neuraxial and retrobulbar blocks. The present randomized blinded controlled study was conducted to evaluate the effect of the addition of clonidine to local anaesthetic mixture on the quality, onset time, duration of peribulbar block, perioperative(More)
A 2-month-old male baby undergoing penetrating keratoplasty (PKP) under general anesthesia developed bradycardia and a decrease in heart rate to 53 b x min(-1) when stay sutures were taken through the superior and inferior recti. A bolus of 0.1 mg intravenous atropine resulted in tachycardia of up to 180-220 b x min(-1), which persisted for 35 min. After(More)
Case series A case note review identified 11 eyes of eight consecutive patients with Terson’s syndrome (age range 27–56 years, M:F = 1:1) referred to the West of England Eye Unit between 1996 and 2004. Surgery was performed for non-resolving vitreous haemorrhage 1– 6 months from date of referral. Ten eyes had three port pars plana vitrectomy and one eye had(More)
with familial Mediterranean fever. Cryopyrin appears to play a role in innate immune function by regulating the production of proinflammatory cytokines. Cryopyrin expression is also very similar in human and mouse. Significant expression of cryopryin occurs in mouse eye and skin tissue, which is consistent with symptoms observed in human(More)
BACKGROUND The WHO seeks to control trachoma as a public health problem in endemic areas. Achham District in western Nepal was found to have TF (trachoma follicular) above 20% in a 2006 government survey, triggering 3 annual mass drug administrations finishing in 2010. Here we assess the level of control that has been achieved using surveillance for(More)
BACKGROUND/AIMS Prevalence estimates and treatment decisions for trachoma are based entirely on ocular clinical examination. The aim of the current study is to demonstrate that ophthalmic assistants can be trained and certified to provide trachoma grading within a single day. METHODS Conjunctival photographs from an area with endemic trachoma were(More)
BACKGROUND The World Health Organization (WHO) now requires a second surveillance survey for trachoma after an impact assessment has found follicular trachoma (TF) <5% to determine if re-emergence has occurred. Using new WHO guidelines, we undertook surveillance surveys, and determined the prevalence of infection and antibody positivity, in two districts in(More)
PURPOSE Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from(More)