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- Publications
- Influence
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.
- S. Singh, Saibaba Vobbalareddy, +5 authors Y. K. Rao
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 April 2004
The effect of methanesulfonamide (MeSO(2)NH) group on COX-2 inhibitory activity of 1,5-diarylpyrazole is described. While this group being at position-4 of the N(1)-phenyl ring was found to be… Expand
2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
- S. Singh, Saibaba Vobbalareddy, +9 authors K. R. Yeleswarapu
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 23 August 2004
Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro cyclooxygenase (COX-1/COX-2) inhibitory activity. The variations at/around… Expand
N-acylated sulfonamide sodium salt: a prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors.
- S. Singh, Saibaba Vobbalareddy, +5 authors J. Iqbal
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 August 2006
Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl)… Expand
Methanesulfonamide Group at Position-4 of the C-5-Phenyl Ring of 1,5-Diarylpyrazole Affords a Potent Class of Cyclooxygenase-2 (COX-2) Inhibitors.
- S. Singh, Saibaba Vobbalareddy, +5 authors Y. K. Rao
- Chemistry
- 17 August 2004
N‐Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional 2‐Hydroxymethyl‐4‐(5‐phenyl‐3‐trifluoromethyl‐pyrazol‐1‐yl) Benzenesulfonamide Class of COX‐2 Inhibitors.
- S. Singh, Saibaba Vobbalareddy, +5 authors J. Iqbal
- Chemistry
- 7 November 2006
Identification of 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-pyrazol-1-yl]-N-propionylbenzenesulfonamide sodium as a potential COX-2 inhibitor for oral and parenteral administration.
- S. Singh, Saibaba Vobbalareddy, +7 authors J. Iqbal
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 December 2006
Synthesis of prodrugs of orally active COX-2 inhibitor 3 involving sulfamoyl (SO(2)NH(2)) and hydroxymethyl (CH(2)OH) groups, and their biological evaluation are described. Of these prodrugs, the… Expand