Sai Prasanth Chamarthy

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To present a calorimetry-based approach for estimating the initial (at the onset of annealing) relaxation time (τ 0) of organic amorphous solids at relatively low temperatures, and to assess the temperature where molecular mobility of the amorphous drug is reduced to a level comparable with the desired shelf-life of the product. Values of τ 0 for six(More)
To develop a calorimetry-based model for estimating the time-dependence of molecular mobility during the isothermal relaxation of amorphous organic compounds below their glass transition temperature (T g). The time-dependent enthalpy relaxation times of amorphous sorbitol, indomethacin, trehalose and sucrose were estimated based on the nonlinear Adam‐Gibbs(More)
The purpose of this investigation is to study the effect of dehydration conditions of raffinose pentahydrate (RF.5H2O) on the physical properties and functionality of the resulting material. Crystalline RF.5H2O was dehydrated at two temperatures, 80 degrees C and 110 degrees C, producing the amorphous anhydrous form (RF.am). The dehydration temperature had(More)
The purpose of this study is to illustrate, with a controlled example, the influence of raw material variability on the excipient’s functionality during processing. Soluble starch was used as model raw material to investigate the effect of variability on its compaction properties. Soluble starch used in pharmaceutical applications has undergone a(More)
The enthalpy relaxation of amorphous salicin, used as model organic glass of pharmaceutical relevance, was investigated using a combination of DSC measurements and theoretical simulations. The combined approach makes it possible to discern between the effect of the glass forming properties of the material and the effects of the thermal history and(More)
The purpose of this study is to provide a quantitative characterization of the thermal behavior of amorphous organic pharmaceutical compounds across their glass transition temperature, and to assess their molecular mobility as a function of temperature and time by combining theoretical simulations with experimental measurements using differential scanning(More)
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