Sai Prasad N Iyer

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Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been elusive. Using a genetic approach, we recently identified Niemann-Pick C1-Like 1 (NPC1L1) as a critical mediator of cholesterol absorption and an essential component of the ezetimibe-sensitive pathway.(More)
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the small intestine is poorly defined. We show that Niemann-Pick C1 Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal(More)
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol into absorptive enterocytes in the intestine is not fully defined on a molecular level, and the role of NPC1L1 in maintaining whole body cholesterol homeostasis is not(More)
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors. To investigate whether receptor biology could influence immune responses to gp120, we studied its interaction with human, monocyte-derived dendritic cells (MDDCs) in vitro. Gp120 from the HIV-1 strain JR-FL(More)
SOSIP gp140 trimers represent a soluble, stabilized, proteolytically cleaved form of the HIV-1 envelope (Env) glycoproteins. SOSIP gp140 derived from a subtype A HIV-1 isolate, KNH1144, forms exceptionally stable trimers that resemble virion-associated Env in antigenicity and topology. Here, we used electron microscopy to demonstrate that KNH1144 SOSIP(More)
HIV type 1 (HIV-1) envelope is a noncovalent trimer of gp120-gp41 heterodimers, and its lability has hindered structural studies. SOSIP gp140 is a soluble, proteolytically mature form of the HIV-1 envelope wherein gp120-gp41 interactions are stabilized via a disulfide bond and gp41 contains an additional trimer-stabilizing point mutation. We describe the(More)
Starting from the recently obtained 2PN accurate forms of the energy and angular momentum fluxes from inspiralling compact binaries, we deduce the gravitational radiation reaction to 2PN order beyond the quadrupole approximation – 4.5PN terms in the equation of motion – using the refined balance method proposed by Iyer and Will. We explore critically the(More)
We have evaluated the centrifugal force acting on a fluid element and the ellipticity of the fluid configuration, which is slowly rotating, using the Hartle-Thorne solution for different equations of state. The centrifugal force shows a maximum in every case, whereas the reversal in sign could be seen in only one case, and the system becomes unstable in(More)
Using the optical reference geometry approach, we have derived in the following , a general expression for the ellipticity of a slowly rotating fluid configuration using Newtonian force balance equation in the conformally projected absolute 3-space, in the realm of general relativity. Further with the help of Hartle-Thorne (H-T) metric for a slowly rotating(More)
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