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Successful Clinical Implementation of Corneal Epithelial Stem Cell Therapy for Treatment of Unilateral Limbal Stem Cell Deficiency
The corneal epithelium is maintained by a population of stem cells known as limbal stem cells (LSCs) due to their location in the basal layer of the outer border of the cornea known as the limbus.Expand
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Successful Application of Ex Vivo Expanded Human Autologous Oral Mucosal Epithelium for the Treatment of Total Bilateral Limbal Stem Cell Deficiency
Ocular surface reconstruction with ex vivo expanded limbal stem cells (LSCs) is a widely used clinical treatment for patients with limbal stem cell deficiency (LSCD). This is not applicable toExpand
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Loss of corneal epithelial stem cell properties in outgrowths from human limbal explants cultured on intact amniotic membrane.
BACKGROUND The corneal epithelium is renewed by stem cells located at the limbus, the so-called limbal stem cells (LSCs). Absence, damage or loss of the LSC population leads to the painful andExpand
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Urrets-Zavalia syndrome following penetrating keratoplasty for keratoconus
BackgroundUrrets-Zavalia syndrome (UZS) consists of a fixed dilated pupil associated with iris atrophy. It is a poorly understood complication following penetrating keratoplasty (PKP) for keratoconusExpand
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Stem cell therapies for ocular surface disease.
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused byExpand
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The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony‐Forming Efficiency, and the Limbal Stem Cell Phenotype
Nerve growth factor (NGF) has demonstrated great benefit in the treatment of neurotrophic corneal ulcers. There is evidence for multiple modes of action in promoting corneal healing, but onlyExpand
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Vitamin A deficiency due to chronic malabsorption: an ophthalmic manifestation of a systemic condition
A 47-year-old woman presented with a 4-week history of progressive loss of vision, first manifesting as night blindness. Additionally, the patient reported frequent severe episodes of diarrhoea overExpand
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Toxic epidermal necrolysis: the red eye and red herrings in casualty
A 38-year-old woman presented to casualty with bilateral red eyes associated with a recent upper respiratory tract infection. This was initially diagnosed as conjunctivitis, however systemic reviewExpand
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Corneal Epithelial Stem Cells and Their Therapeutic Application
The cornea is the clear window at the front of the eye and its clarity is vital for the transmission of light to the retina at the back of the eye for visual perception. The surface of the cornea isExpand
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Manufacturing Decision Support Systems
TLDR
This book provides a forum for research and applications dealing with the design, the development and the implementation of decision support systems in the manufacturing domain. Expand
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