Sagar S. Chawla

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The differentiation and proliferation of neural stem/progenitor cells (NPCs) depend on various in vivo environmental factors or cues, which may include an endogenous electrical field (EF), as observed during nervous system development and repair. In this study, we investigate the morphologic, phenotypic, and mitotic alterations of adult hippocampal NPCs(More)
INTRODUCTION Musculoskeletal disease (MSD) is a major cause of disability in the global burden of disease, yet data regarding the magnitude of this burden in low and middle-income countries (LMICs) are lacking. The Surgeons OverSeas Assessment of Surgical Need (SOSAS) survey was designed to measure incidence and prevalence of surgically treatable(More)
OBJECTIVE To determine the prognosis of patients with non-secretory myeloma. METHODS We studied 124 patients diagnosed with multiple myeloma who had no monoclonal protein detected on serum and urine immunofixation at diagnosis and on all subsequent follow-up testing (non-secretory myeloma). The overall survival (OS) of patients with non-secretory myeloma(More)
Globally, an estimated 2 billion people lack access to surgical and anesthesia care. We sought to pool results of anesthesia care capacity assessments in low- and middle-income countries (LMICs) to identify patterns of deficits and provide useful targets for advocacy and intervention. A systematic review of PubMed, Cochrane Database of Systematic Reviews,(More)
The list of asthma masqueraders grows, emphasizing the need for a careful analysis of the patient suffering from cough, wheezing and/or dyspnea. The present case report describes a 23-year-old patient with spastic vocal cord adduction, initially treated as bronchial asthma. Severe disruption in her arterial blood gases was present. The vocal cord adduction(More)
Aldehyde dehydrogenase (ALDH) activity is demonstrated in two mutant strains ofD. melanogaster lacking active aldehyde oxidase (ALDOX). The levels of ALDH activity are compared with those found for the wild strain ofD. melanogaster and its sibling speciesD. simulans. These data provide a rational explanation for the capacity of ALDOX-null flies to detoxify(More)
INTRODUCTION Although two billion people now have access to clean water, many hospitals in low- and middle-income countries (LMICs) do not. Lack of water availability at hospitals hinders safe surgical care. We aimed to review the surgical capacity literature and document the availability of water at health facilities and develop a predictive model of water(More)
Ongoing payment reform in dialysis necessitates better patient outcomes and lower costs. Suggested improvements to processes of care for maintenance dialysis patients are abundant; however, their impact on patient-important outcomes is unclear. This systematic review included comparative randomized controlled trials or observational studies with no(More)
Background: Bone marrow-derived mesenchymal stem cells (MSCs) have emerged as beneficial cellular vehicles for nervous system rescue and repair. A better understanding how MSCs are involved in mediating neural repair will facilitate development of novel therapeutic strategies. Methods: In the present study bone marrow-derived MSCs were isolated and(More)
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