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Failures in fracture healing are mainly caused by a lack of vascularization. Adult human circulating CD34+ cells, an endothelial/hematopoietic progenitor-enriched cell population, have been reported to differentiate into osteoblasts in vitro; however, the therapeutic potential of CD34+ cells for fracture healing is still unclear. Therefore, we performed a(More)
The prognostic significance of 1p19q loss in astrocytic gliomas has been inconclusive.We collected 57 gliomas with total 1p19q loss from among 218 cases of WHO grade-II/III gliomas operated at Keio University Hospital between 1990 and 2010. These tumors were classified as oligodendroglial or "astrocytic" by a WHO-criteria-based institutional diagnosis.(More)
BACKGROUND Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals. However, it has been technically difficult to obtain imaging evidence of collateral formation by conventional angiography. METHODS AND RESULTS Peripheral blood CD34+ and CD34- cells were(More)
RATIONALE Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic growth factors or bone marrow (BM) cells, recent clinical trials have revealed less benefit from these therapies than expected. OBJECTIVE We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a(More)
The discovery of three planetary companions around HR 8799 (Marois et al. 2008) marked a significant epoch in direct imaging of extrasolar planets. Given the importance of this system, we re-analyzed H band images of HR 8799 obtained with the Subaru 36-elements adaptive optics (AO) in July 2002. The low-order AO imaging combined with the classical(More)
Genetic subgrouping of gliomas has been emphasized recently, particularly after the finding of isocitrate dehydrogenase 1 (IDH1) mutations. In a previous study, we investigated whole-chromosome copy number aberrations (CNAs) of gliomas and have described genetic subgrouping based on CNAs and IDH1 mutations. Subsequently, we classified gliomas using simple(More)
Schwannomas of the abducens nerve are uncommon. Nineteen cases have been reported in the literature and are classified into two types: Type 1, in the cavernous sinus, and Type 2, in the prepontine area. However, a dumbbell-shaped type has not yet been reported. Here we report the first case of a dumbbell-shaped abducens schwannoma and classify this type(More)
We introduce a near-infrared camera named coronagraph imager with adaptive optics (CIAO) mounted on the Subaru 8m telescope. Combined with the Subaru 36 elements adaptive optics (AO), CIAO can produce nearly diffraction limited image with ∼0.07 arcsec FWHM at K band and high dynamic range imaging with ∼10 mag difference at 1 arcsec separation under typical(More)