Saeed-ul-Hasan Khan

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Bone marrow-derived mesenchymal stem cells (MSCs) are known to specifically migrate to and engraft at tumour sites. Understanding interactions between cancer cells and MSCs has become fundamental to determining whether MSC-tumour interactions should be harnessed for delivery of therapeutic agents or considered a target for intervention. Breast Cancer Cell(More)
The tumour microenvironment is believed to be involved in development, growth, metastasis, and therapy resistance of many cancers. Here we show survivin, a member of the inhibitor of apoptosis protein (IAP) family, implicated in apoptosis inhibition and the regulation of mitosis in cancer cells, exists in a novel extracellular pool in tumour cells.(More)
Kisspeptin, a KISS1 gene product, stimulates GnRH neurons in the hypothalamus, but some recent studies have also suggested a direct effect on gonads. We aimed to localise Kiss and Kiss1 receptor (Kiss1r) in adult rhesus monkey testis. Expression of Kiss1 and Kiss1r was detected in testicular tissue of rhesus monkey using immunohistochemistry and reverse(More)
Previously we showed that tirapazamine (SR 4233, Win 59075) is cytotoxic towards hepatocytes under conditions of hypoxia but not in 10% or 95% oxygen and that bioreduction by DT-diaphorase or cytochrome P450 is not a major pathway. In the present study, we report that tirapazamine is highly cytotoxic to isolated rat hepatocytes maintained under 1% oxygen(More)
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