Saeed Alshahrani

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Gary E Shull19
John N Lorenz18
T Doetschman15
J J Duffy15
M L Miller15
7Mauricio Di Fulvio
6Mohammed Mashari Almutairi
5Abdullah Sener
5Alain Boom
5Myrna Virreira

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2011
2017
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Expression of the Slc12a1 gene in pancreatic β-cells: molecular characterization and in silico analysis.
The solute carrier protein family 12 group A, member one (Slc12a1) and two (Slc12a2) encode several splice variants of the kidney-specific and the ubiquitous isoforms, respectively, of the bumetanide (BTD)-sensitive Na-dependent K2Cl co-transporter. The Slc12a2 co-transporter is involved in the maintenance of a high intracellular chloride concentration… (More)
Enhanced insulin secretion and improved glucose tolerance in mice with homozygous inactivation of the Na(+)K(+)2Cl(-) co-transporter 1.
The intracellular chloride concentration ([Cl(-)](i)) in β-cells plays an important role in glucose-stimulated plasma membrane depolarisation and insulin secretion. [Cl(-)](i) is maintained above equilibrium in β-cells by the action of Cl(-) co-transporters of the solute carrier family 12 group A (Slc12a). β-Cells express Slc12a1 and Slc12a2, which are… (More)
Cultural acceptance of robotic telestroke medicine among patients and healthcare providers in Saudi Arabia
OBJECTIVE To determine the degree of satisfaction and acceptance of stroke patients, their relatives, and healthcare providers toward using telestroke technology in Saudi Arabia. METHODS A cross-sectional study was conducted between October and December 2012 at King Abdulaziz Medical City, Ministry of National Guard Affairs, Riyadh, Saudi Arabia. The… (More)
Rapid determination of the thermal nociceptive threshold in diabetic rats.
Painful diabetic neuropathy (PDN) is characterized by hyperalgesia i.e., increased sensitivity to noxious stimulus, and allodynia i.e., hypersensitivity to normally innocuous stimuli. Hyperalgesia and allodynia have been studied in many different rodent models of diabetes mellitus. However, as stated by Bölcskei et al, determination of "pain" in animal… (More)
Sensitivity analysis of predictive modeling for responses from the three-parameter Weibull model with a follow-up doubly censored sample of cancer patients
The purpose of this paper is to derive the predictive densities for future responses from the three-parameterWeibullmodel given a doubly censored sample. The predictive density for a single future response, bivariate future response, and a set of future responses has been derived when the shape parameter α is unknown. A real data example representing 44… (More)
The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states
Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC). However, chronic volume depletion and diuresis are minimal while lowered blood pressure (BP) is maintained on thiazides. Thus, a… (More)
Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice
The products of the Slc12a1 and Slc12a2 genes, commonly known as Na(+)-dependent K(+)2Cl(-) co-transporters NKCC2 and NKCC1, respectively, are the targets for the diuretic bumetanide. NKCCs are implicated in the regulation of intracellular chloride concentration ([Cl(-)]i) in pancreatic β-cells, and as such, they may play a role in glucose-stimulated plasma… (More)
Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting
Contribution of salt wasting and volume depletion to the pathogenesis of hypercalciuria and hyperphosphaturia is poorly understood. Pendrin/NCC double KO (pendrin/NCC-dKO) mice display severe salt wasting under basal conditions and develop profound volume depletion, prerenal renal failure, and metabolic alkalosis and are growth retarded. Microscopic… (More)
Impact of Web Technologies on Student-lecturer Expert Power Relationship
Expert power is “the power that comes from having knowledge and expertise in a particular area” (Nazarko, 2004). In the history of the development of higher education, the relationship between the lecturer and the students has changed because of many different factors. Before the internet and web revolution, the lecturer used to be the main information… (More)
Vascular contractile reactivity in hypotension due to reduced renal reabsorption of Na+ and restricted dietary Na+
Reduced renal Na+ reabsorption along with restricted dietary Na+ depletes intravascular plasma volume which can then result in hypotension. Whether hypotension occurs and the magnitude of hypotension depends in part on compensatory angiotensin II-mediated increased vascular resistance. We investigated whether the ability of vascular resistance to mitigate… (More)