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15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has a dual action of stimulating anti-inflammation and anti-proliferation when exogenously administered at high doses. However, at lower doses, it can be toxic inducing opposite actions, ie, stimulation of both inflammation and cell proliferation. This biphasic phenomenon of 15d-PGJ2 is believed to be due to its(More)
Nerve growth factor (NGF) is the first characterized member of the neurotrophin family. It is known for its crucial role in survival, differentiation and maintenance of neurons both in peripheral and central nervous system. In addition to its neurotrophic role, NGF has been also proposed to influence the immune system. Recent studies indicate that in(More)
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