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Polymorphonuclear leukocyte-dominated airway inflammation is a major component of cystic fibrosis (CF) lung disease and may be associated with CF transmembrane conductance regulator (CFTR) dysfunction as well as infection. Mutant DeltaF508 CFTR is mistrafficked, accumulates in the endoplasmic reticulum (ER), and may cause "cell stress" and activation of(More)
Several mutations in the genes encoding α-crystallin (α-Cry) subunits have been indicated to cause cataract diseases in human. Also, elevation in calcium level has been shown to induce aggregation of α-Cry which is accompanied with a significant reduction in its chaperone function. In some pathological conditions, the simultaneous incidence of α-Cry(More)
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