Sadaaki Inutsuka

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BACKGROUND Our objective was to evaluate the long-term benefit of R2/3 lymph node dissection compared with that of R1, even in node-negative cases. METHODS We analyzed clinicopathologic data on 373 surgically treated patients with early gastric cancer and without microscopic nodal involvement. RESULTS Five- and 10-year survival rates for patients(More)
Fuyuan Country, in Yunnan Province, China has an extremely high lung cancer mortality both in males and non-smoking females. Out of 5768 deaths, 588 patients died of malignant diseases. Lung cancer was the number one cause of death among malignant diseases both in males and females. The rate of lung cancer death to the whole of malignant diseases was 56.2%(More)
A 58-year-old woman with a mesothelial cyst of the diaphragm showed high level of serum Tissue Polypeptide Antigen (TPA) and cyst fluid TPA. Mesothelial cells of the cyst may excrete TPA and TPA was accumulated in the cysts. The measurement of tumor marker such as TPA of the serum or of the content of the cyst is useful in observation of the clinical course.
A 64-year-old woman had gastric heterotopic of the duodenal bulb without any specific complaints. The lesion with irregular excrescence was diagnosed by means of target biopsies through endoscopy, and 3 years later, no noteworthy changes were observed in the endoscopic findings of the lesion, and it was also proved by an endoscopic Congo red test that the(More)
Manganese superoxide dismutase (MnSOD) is an important superoxide anion scavenger located in mitochondria and protects cells from the damage caused by reactive oxygen species. The oxygen balance has been reported to be related to the occurrence and invasiveness of malignant tumors. The aim of the current study was to elucidate the clinicopathological(More)
We conducted a phase II trial of a regimen that combined cisplatin (CDDP), carboplatin (CBDCA), and vindesine (VDS) in previously untreated patients with non-small cell lung cancer (NSCLC) to evaluate the efficacy and safety of the regimen. Thirty-five patients with inoperable NSCLC entered the study. Cisplatin (CDDP 80 mg/m2) was administered on day 1, and(More)
BACKGROUND The mechanisms underlying the frequent development of carcinomas associated with ulcerative colitis (UC) are not understood. Cellular antioxidants play a crucial role in protection against neoplastic disease. The purpose of this study is to investigate a critical balance between free radical activity and the antioxidant defense system in(More)
The plasma copper level (PCL) and plasma zinc level (PZL) were determined in 126 patients: 54 had carcinomas of which 40 were carcinomas of the digestive organs, 37 had benign lesions, and 35 were without disease. The PCL increased and the PZL decreased significantly in the group with carcinoma of the digestive organs. The CuHZn ratio was not only(More)
BACKGROUND Although the molecular and biologic changes in G1/S cyclins have been well characterized, alterations in G2/M cyclin and its possible roles in cell proliferation and metastatic behavior remain to be elucidated. METHODS The cyclin B1 expression immunohistochemically determined in 109 patients with colorectal cancer was investigated from the(More)
We examined the relationship between aryl hydrocarbon hydroxylase (AHH) and the frequency of a MspI mutation in the 3'-flanking region of cytochrome P450 (CYP) 1A1 (MspI polymorphism) and another mutation in exon 7 (Ile-Val polymorphism) in 84 healthy male subjects in Fukuoka, Japan. AHH inducibility (3-methylcholanthrene (MC)-induced AHH(More)