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TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice.

• Hiroyuki Yoshida, Makiya Nishikawa, +5 authors Yoshinobu Takakura
• The journal of gene medicine
• 2009

BACKGROUND The type I interferon (IFN) response to DNA/cationic liposome complex, or lipoplex, has been reported in cultured cells, but little is known about the response in vivo. Studies of the… (More)

Determination of p-glycoprotein ATPase activity using luciferase.

• T. Matsunaga, Eiji Kose, Sachiyo Yasuda, Hirohiko Ise, Uichi Ikeda, Shigeru Ohmori
• Biological & pharmaceutical bulletin
• 2006

We investigated whether P-glycoprotein (P-gp) ATPase activity of Caco-2 cell membranes could be estimated by measuring consumption of ATP using luciferin-luciferase reaction, and whether the results… (More)

Cellular activation by plasmid DNA in various macrophages in primary culture.

• Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno, Yoshinobu Takakura
• Journal of pharmaceutical sciences
• 2008

Macrophages are an important group of cells responsible for the inflammatory response to unmethylated CpG dinucleotide (CpG motif) in plasmid DNA (pDNA) via Toll-like receptor 9 (TLR9). This finding… (More)

Comparison of the type of liposome involving cytokine production induced by non-CpG Lipoplex in macrophages.

• Sachiyo Yasuda, Hiroyuki Yoshida, Makiya Nishikawa, Yoshinobu Takakura
• Molecular pharmaceutics
• 2010

To improve the transfection efficiency of plasmid DNA (pDNA) into cells, various types of cationic liposome have been used to prepare pDNA/cationic liposome complexes (lipoplexes). It is well-known… (More)

Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA.

• Hiroyuki Yoshida, Makiya Nishikawa, +4 authors Yoshinobu Takakura
• Cytokine
• 2012

Fibronectin (FN) is known to have four DNA-binding domains although their physiological significance is unknown. Primary murine peritoneal macrophages have been shown to exhibit markedly lower… (More)

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