Sachiyo Manabe

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To protect against virus infections, the new technology of the virus removal membrane has been developed. The novel virus removal filter PLANOVA is validated for virus removal, that is, reproducible and predictable. The removal is based on the sieving mechanism. The removal of viruses by PLANOVA with a given mean pore size ranging between 10 and 75 nm is(More)
A concentrated live retrovirus is required for in vitro experiments. A cuprammonium-regenerated cellulose hollow fiber, termed BMM, originally developed for biohazardous viral removal, was used to concentrate two different retroviruses, an ecotropic murine leukemia virus (MuLV) and human immunodeficiency virus (HIV). The BMM was useful for concentrating(More)
A newly synthesized substrate, 3-hydroxybutyrylglycyl-glycyl-glycine (3HB-GGG), was applied to the assay of ACE-inhibiting activity to overcome the smaller selectivity and sensitivity of the conventional method. In this study, an ACE-inhibiting assay was improved by the use of a water-soluble tetrazolium salt,(More)
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