Sachin Yende

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Severe sepsis is a leading cause of death in the United States and the most common cause of death among critically ill patients in non-coronary intensive care units (ICU). Respiratory tract infections, particularly pneumonia, are the most common site of infection, and associated with the highest mortality. The type of organism causing severe sepsis is an(More)
While sepsis is a leading cause of acute kidney injury in critically ill patients, the relationship between immune response and acute kidney injury in less severely ill patients with infection is not known. Here we studied the epidemiology, 1-year mortality, and immune response associated with acute kidney injury in 1836 hospitalized patients with(More)
BACKGROUND Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance. METHODS The Health Aging and Body Composition (Health ABC) study is a prospective observational cohort of well functioning individuals aged 70-79 years. A cross(More)
RATIONALE Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear. OBJECTIVE To ascertain role of preinfection inflammatory markers on susceptibility to community-acquired pneumonia (CAP). METHODS Longitudinal analysis over 6.5(More)
OBJECTIVE Platelet dysfunction is a common cause of bleeding after coronary artery bypass graft surgery. This study explores the effects of clopidogrel on bleeding complications after coronary artery bypass graft surgery. DESIGN Prospective observational study of patients undergoing coronary artery bypass graft. SETTING Tertiary care center. PATIENTS(More)
OBJECTIVE To examine the association of statin use with clinical outcomes and circulating biomarkers in community-acquired pneumonia and sepsis. DESIGN Multicenter inception cohort study. SETTING Emergency departments of 28 U.S. hospitals. PATIENTS A total of 1895 subjects hospitalized with community-acquired pneumonia. INTERVENTIONS None. (More)
OBJECTIVES The epidemiology of chronic critical illness is not well characterized. We sought to determine the prevalence, outcomes, and associated costs of chronic critical illness in the United States. DESIGN Population-based cohort study using data from the United States Healthcare Costs and Utilization Project from 2004 to 2009. SETTING Acute care(More)
BACKGROUND Acceleration of chronic diseases, particularly cardiovascular disease, may increase long-term mortality after community-acquired pneumonia (CAP), but underlying mechanisms are unknown. Persistence of the prothrombotic state that occurs during an acute infection may increase risk of subsequent atherothrombosis in patients with pre-existing(More)
OBJECTIVES Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults. (More)
RATIONALE Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown. OBJECTIVES To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated(More)