Sachin Singhal

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The effects of the antipsychotic clozapine on the function of the cloned alpha(7) subunit of the nicotinic acetylcholine (nACh) receptor expressed in Xenopus oocytes was investigated by using the two-electrode voltage-clamp technique. Clozapine reversibly inhibited nicotine (10 microM)-induced currents in a concentration-dependent manner (300 nM to 90(More)
This article describes the participation of the Image and Text Integration (ITI) group from the U.S. National Library of Medicine (NLM) in the ImageCLEF 2010 medical retrieval track. Our methods encompass a variety of techniques relating to document summarization and text-and content-based image retrieval. Our text-based approaches utilize the Unified(More)
In earlier studies, the volatile anesthetics and the endogenous cannabinoid anandamide have been shown to inhibit the function of alpha(7)-nicotinic acetylcholine receptors. In the present study, interactions between the effects of volatile anesthetics and anandamide on the function of alpha(7)-nicotinic acetylcholine receptors expressed in Xenopus oocytes(More)
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