Sachin Khurana

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To the Editor, Rituximab (anti-CD20) is a chimeric monoclonal antibody and is commonly used in treatment of various lymphomas and nonmalignant immune disorders. Infusion reactions are common following rituximab administration. Cardiotoxicity with rituximab is less frequent, but occasionally arrhythmia is reported. We report here an acute myocardial(More)
Persistent or chronic infection with the hepatitis B virus (HBV) represents one of the most common viral diseases in humans. The hepatitis B virus deploys the hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes. Because of its critical role in countering host defenses, HBx represents an(More)
The liver is one of the commonest sites of metastatic involvement in breast cancer, usually evident as focal lesions on imaging tests. Rarely, the pattern of metastatic spread is so diffuse that it remains radiologically occult. Such patients usually present with signs of hepatic insufficiency without any focal lesions on liver imaging. In such cases, liver(More)
PURPOSE High-dose methotrexate (HDMTX)-based regimens are widely used in osteosarcoma. However, mandatory in-patient treatment with complex pharmacokinetic monitoring requirement precludes its use, especially in resource-constrained settings of low- and middle-income countries (LMICs). METHODS All treatment naive consecutive patients of osteosarcoma were(More)
MANETs are networks capable of communicating in a set of small, low cost, low power sensing devices. A wireless sensor networks is totally based on the limiting factor i.e. energy consumption. A wireless sensor network consists of large number of sensor nodes distributed or scattered in particular network region. MANETs consist of node that is highly(More)
Recent progress in the field of microbial ecology has led to the discovery of novel microbiota in humans. These organisms perform many biochemical functions for the host and are also associated with disease and disease progression. With the help of high-throughput assays, it is possible to survey the human microbiome, which can help elucidate their(More)
Hemoglobin degradation/hemozoin formation, essential steps in the Plasmodium life cycle, are targets of existing antimalarials. The pathway still offers vast possibilities to be explored for new antimalarial discoveries. Here, we characterize heme detoxification protein, PfHDP, a major protein involved in hemozoin formation, as a novel drug target. Using in(More)
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