Sachin Goyal

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Resource-constrained embedded and mobile devices are becoming increasingly common. Cyber foraging, which allows such devices to offload computation to less resource-constrained surrogate machines, enables new and interesting applications for these devices. In this paper, we describe a surrogate infrastructure based on virtual machine technology that allows(More)
Digital Watermarking provides techniques to hide watermarks into digital content to protect it from illegal copy or reproduction. The prevalent techniques of digital watermarking in spatial domain cause the watermarked image to loose its image quality termed as Robustness and fidelity. Several techniques have been devised to optimize the Robustness and(More)
In Digital Watermarking a low energy signal is imperceptibly embedded in another signal. The low energy signal is called watermark. Earlier techniques based on spatial and frequency domain, had the problems of a poor fidelity especially with higher payloads of watermark image. Unsatisfactory value of Peak Signal to Noise Ratio (PSNR) of watermarked image(More)
DNA looping mediated by the Lac repressor is an archetypal test case for modeling protein and DNA flexibility. Understanding looping is fundamental to quantitative descriptions of gene expression. Systematic analysis of LacI•DNA looping was carried out using a landscape of DNA constructs with lac operators bracketing an A-tract bend, produced by varying(More)
Protein-mediated DNA looping is a common mechanism for regulating gene expression. Loops occur when a protein binds to two operators on the same DNA molecule. The probability of looping is controlled, in part, by the basepair sequence of inter-operator DNA, which influences its structural properties. One structural property is the intrinsic or stress-free(More)
Quantitative analysis of single molecule experiments show that adding either of two natural polyamines, spermine or spermidine, produced more compact plectonemes in DNA in physiological concentrations of monovalent salt. They also promoted plectoneme formation at lower values of torsion in measurements of extension versus twist. Quantifying changes in the(More)
We propose a collective approach for harnessing the idle resources (cpu, storage, and bandwidth) of nodes (e.g., home desktops) distributed across the Internet. Instead of a purely peer-to-peer (P2P) approach, we organize participating nodes to act collectively using collective managers (CMs). Participating nodes provide idle resources to CMs, which unify(More)
Sequence-dependent intrinsic curvature of DNA influences looping by regulatory proteins such as LacI and NtrC. Curvature can enhance stability and control shape, as observed in LacI loops formed with three designed sequences with operators bracketing an A-tract bend. We explore geometric, topological, and energetic effects of curvature with an analysis of a(More)
We have determined the change in the number of proteins bound non-specifically to DNA as a function of applied force using force-extension measurements on tethered DNA. Using magnetic tweezers, single molecules of λ DNA were repeatedly stretched and relaxed in the absence and presence of 170 nM λ repressor protein (CI). CI binds to six specific sites of λ(More)
In this paper, we study the stability of an initially straight elastic fibril clamped at one end, while the other end is subjected to a constant normal compressive force and a prescribed shear displacement. We found the buckling load of a sheared fibril to be always less than the Euler buckling load. Furthermore, if the end of the fibril loses adhesion,(More)