Sachin Arora

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Telmisartan, an angiotensin II-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigated whether telmisartan improved the pathophysiology of myocardial infarction in diabetes partially through the PPAR-gamma pathway by assessing a variety of indices, e.g., hemodynamic, biochemical,(More)
The global epidemic of type 2 diabetes demands the rapid evaluation of new and accessible interventions. This study investigated whether Aegle marmelos fruit aqueous extract (AMF; 250, 500 and 1000 mg/kg) improves insulin resistance, dyslipidemia and β-cell dysfunction in high fat diet fed-streptozotocin (HFD-STZ)-induced diabetic rats by modulating(More)
In recent years, novel drug delivery systems (NDDS) have been recognized as an attractive niche for the pharmaceutical and health industry. Among various NDDS, osmotic pumps have matured from their use with laboratory animals to the most reliable controlled release systems for humans. Osmotically controlled drug delivery systems use osmotic pressure for(More)
Captopril when administered intracerebroventricularly (icv) in doses of 100, 300, 500 and 1000 micrograms induced a dose dependent antinociceptive effect in rats. Naloxone pretreatment (10 mg/kg, ip) completely antagonised antinociceptive effect of captopril, suggesting thereby the involvement of brain enkephalinergic system. Captopril 300 micrograms, icv(More)
A workflow defines flow of information and control in a process. Most software solutions for workflow management systems do not model the real world scenario perfectly. Moreover, changes in the workflow result in many modifications to the application. The Mobile Agent paradigm not only provides a richer model for workflow systems that better resembles the(More)
The present study was designed to investigate whether Khamira Abresham Hakim Arshad Wala (KAHAW), a preparation of Unani System of Medicine, is able to attenuate the isoproterenol (ISO)-induced myocardial necrosis on the basis of its effects on hemodynamic, antioxidant, histopathological and ultrastructural parameters. Male Wistar albino rats were(More)
Commiphora mukul commonly known as Guggul is one of the oldest and commonly consumed herb for promoting heart and vascular health. Present study was undertaken to evaluate cardioprotective potential of Commiphora mukul against isoprenaline-induced myocardial necrosis in rats. Wistar albino rats were divided into three main groups: sham (saline only),(More)
The present study was designed to investigate the characteristics of diabetes mellitus induced by different doses of Streptozotocin in mice as assessed by blood glucose concentration. Swiss albino mice of either sex were intraperitoneally administered single dose of Streptozotocin 180 mg/kg, or 100 mg/kg and multiple low dose of Streptozotocin 40 mg/kg/day.(More)
Telmisartan is a unique angiotensin II receptor blocker with an additional peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activity. The present study has been designed to investigate whether telmisartan treatment attenuates the development of acute myocardial infarction in isoproterenol-treated rats by restoring hemodynamic, biochemical,(More)
1 Saurabh Bharti, 1 Sachin Arora, 1 Dharamvir S Arya* Cardiovascular and Diabetes Research Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India *Corresponding author,Associate Professor,Department of Pharmacology,All India Institute of Medical Sciences,New Delhi –110 029, India;Tel.: +91 11 26594266; Fax:(More)