Sachiko Suga

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The murine local lymph node assay (LLNA) is an immunologically based test of the sensitizing potential of immunotoxicants, but also evaluates immunosuppressive potential with good sensitivity and specificity. We conducted the LLNA with calcineurin inhibitors (tacrolimus and cyclosporin A), antimetabolites (methotrexate and azathioprine), steroids(More)
Electrical stimulation of the medial amygdala (AMY) elicited antidromic action potentials in neurons in the preoptic area (POA) and the lateral septum (LS) of 36 urethane-anesthetized ovariectomized female rats, which were either treated with estrogen o not treated. The extracellular potentials from the two sites showed similar characteristics, with the(More)
Sodium dehydroacetate (DHA-S) is used as a food additive, preservative and antimicrobial agent. Repeated oral administration of DHA-S in rats induced severe hemorrhage in multiple organs and prolongation of blood coagulation factors. To determine the mechanism of hemorrhage, the protective effect of vitamin K (VK) was investigated. Increased VK-dependent(More)
Irradiation effects on cancer toxin, "toxohormone", in tumor-bearing hosts were investigated. Crude toxohormone fractions were prepared from preoperatively co&0-irradiated human gastric cancer by the method of Yunoki and Griffin. 1) It was demonstrated tha t Co&0-irradiation reduced the liver catalase depressing action of the crude toxohormone fractions,(More)
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