Sachiko Matsui

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We have previously reported that cofilin, an actin-binding protein, plays an important role in phagocyte functions, such as respiratory burst, phagocytosis, and chemotaxis. On the other hand, it was recently found that LIM motif-containing kinase (LIMK) phosphorylates cofilin. In this work, we investigated the roles of LIMK in activated phagocytes. The(More)
We recently demonstrated that glycyrrhizin (GL) and its derivatives down-regulate TNFalpha- and IL-4-induced eotaxin 1 production by the human fetal lung fibroblast line HFL-1 at protein or mRNA levels. In particular, the GL derivative hetero-30-OH-GL (3beta-[(2-O-beta-D-glucopyranuronosyl-beta-D-glucopyranuronosyl)oxy]-olean-11,13(18)-dien-30-ol) showed(More)
Glycyrrhizin (GL) is known to have various immunomodulating activities and has long been used clinically as an anti-allergic and anti-hepatitis agent. While the potency of GL against lung inflammatory diseases has been expected, the effect of GL on the lung has been poorly understood. Lung fibroblasts are known as a potent producer of inflammatory(More)
A scientometric analysis of social science literature is tried by using the machine-readable files of theIBSS 1981–1985. This is a comprehensive international bibliography in social sciences including cultural anthropology, economics, political science and sociology. Data used were 40,313 monograph records in theIBSS files. First, the number of scholarly(More)
The purpose of this paper is to propose a new method of questionnaire data analysis. Considering convenient answering and subsequent data processing, multiple-item selection typed questions are often used. However, it is sometimes difficult to select one corresponding item from multiple items in case that the definitions of each item are inexplicit, or(More)
We previously reported that an actin-binding protein, cofilin, is involved in superoxide production, phagocytosis, and chemotaxis in activated phagocytes through cytoskeletal reorganization. To elucidate the functions of cofilin in greater detail we tried to identify cofilin-binding proteins by using a phage-displayed cDNA library constructed from human(More)
Introduction: The increasing population of elderly with dementia in Japan poses a serious public health issue that must be addressed. Behavioral and psychological symptoms of dementia (BPSD) can affect and influence care provided by caregivers. Thus, examining caregiver attitudes toward elderly with dementia is warranted. Objectives: The purpose of this(More)
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