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This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available(More)
OBJECTIVE We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS The brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive(More)
AIM To investigate the relationship between plasma betatrophin concentrations and insulin secretion capacity in people with Type 2 diabetes. METHODS Glucagon stimulation tests (1 mg) were performed in 70 people with Type 2 diabetes after an overnight fast. Plasma betatrophin concentrations were measured using an enzyme-linked immunosorbent assay. Insulin(More)
Since infection with Helicobacter pylori has been suggested to play a pathogenic role in diabetes mellitus, we investigated whether eradication therapy for H. pylori might affect glycemic control in Japanese subjects with type 2 diabetes. A total of 72 subjects (55 males, 17 females; aged 63.7 years) with type 2 diabetes who received eradication therapy for(More)
Anti-A and anti-B blood group antibodies in the cynomolgus monkey sera were serologically characterized. 2-Mercaptoethanol (2-ME) inactivated these antibodies of both group-A and group-B sera. Furthermore, soluble human ABH substances neutralized these antibody activities. However, these activities were not inhibited by anti-human IgG or IgA serum but by(More)
A 64-year-old woman was referred to our center presenting with thirst, malaise, and pain in both legs which occurred one week before admission. She was revealed to have hyperglycemia and diabetic ketoacidosis (DKA). After therapy for diabetic ketoacidosis was started, her blood glucose levels were improved, but urinary ketone body excretion persisted.(More)
Anti-A and anti-B blood group antibody levels were determined with serum samples of 583 cynomolgus monkeys of group-A and group-B, aged from 4 days to 15 years or more. Eight group-A infants free from anti-B antibody at ages of 4 to 25 days were consecutively followed up for the appearance of anti-B antibody. It appeared at ages between 68 and 160 days.(More)
V arious noninvasive in vivo assessments have recently been applied to the estimation of atherosclerosis in subjects with diabetes. The measurement of pulse-wave velocity (PWV) has been popular with the advance of apparatus, especially in Japan (1–3). However, it remains unknown whether PWV may be valid and reproducible, especially in diabetic study(More)
UNLABELLED Aims/Introduction:  We examined whether levels of glutamic acid decarboxylase autoantibodies (GADAb) might show the clinical heterogeneity of adult Japanese diabetes. MATERIALS AND METHODS   In this cross-sectional study, the serum levels of GADAb were measured in a total of 1857 consecutive adult diabetic patients aged 20 years or older. The(More)