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Significance of lipid mediators in corneal injury and repair.

• Sachidananda Kenchegowda, Haydee E P Bazan
• Journal of lipid research
• 2010

Corneal injury induces an inflammatory reaction and damages the sensory nerves that exert trophic influences in the corneal epithelium. Alterations in normal healing disrupt the integrity and… (More)

EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.

• Sachidananda Kenchegowda, Nicolas G Bazan, Haydee E P Bazan
• Investigative ophthalmology & visual science
• 2011

PURPOSE To investigate the effect of epidermal growth factor (EGF) on lipoxin A4 (LXA4) synthesis and how it regulates corneal epithelial wound healing through mitogen-activated kinases,… (More)

Lipoxin A₄ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma.

• Azucena H. Kakazu, Jiucheng He, Sachidananda Kenchegowda, Haydee E P Bazan
• Experimental eye research
• 2012

Platelet-activating factor (PAF) is a bioactive lipid mediator with strong inflammatory properties. PAF induces the expression and activation of metalloproteinase-9 (MMP-9) in corneal epithelial… (More)

Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery.

• Sachidananda Kenchegowda, Jianfeng He, Haydee E P Bazan
• Prostaglandins, leukotrienes, and essential fatty…
• 2013

Alterations in corneal innervations result in impaired corneal sensation, severe dry eye and damage to the epithelium that may in turn lead to corneal ulcers, melting and perforation. These… (More)

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