Sachi Sri Kantha

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The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 microliter per min for 6 hr (2300-0500 hr) through chronically implanted microdialysis probes or infusion cannulae. Among the administrations of PDG2 by dialysis probes (n =(More)
By his own admission, Albert Einstein, 'started to talk comparatively late ... certainly not younger than three', and also had 'poor memory of words', during his childhood years. If lesions in Brodmann Area 39 of the cerebral hemisphere results in dyslexia, the 1985 report on the study of Einstein's brain that the neuron:glial ratio of Area 39 in the left(More)
Prostaglandin (PG) D2 has been postulated to be an endogenous sleep-promoting factor. Biosynthesis of PGD2 is catalyzed by PGD synthase (prostaglandin-H2 D-isomerase, EC 5.3.99.2), the activity of which is inhibited by inorganic selenium compounds such as SeCl4 and Na2SeO3. We recently examined the effect of intracerebroventricular administration of these(More)
The beneficial effects in humans of ingesting fish oils have attracted much attention among medical scientists and nutritionists recently. Human studies conducted in populations of Eskimos, Japanese, and Caucasians since 1970 are reviewed in this paper. The evidence shows that a diet rich in omega-3 fatty acids significantly reduces plasma cholesterol and(More)
141 obtained during interviews with the ex-inhabitants of an abandoned village near the Igarapé do Urucú (a left affluent of the Rio Sucundurí, along the Serra do Sucundurí) indicates that M. acariensis and another species of marmoset with blackish hairs occur in the area. As M. melanurus has been confirmed as occurring in the Sucundurí Mountains (Noronha,(More)
Though somnambulism (sleepwalking) is a well-recognized sleep disorder in humans, a biomedical literature search in Medline and Primate Literature bibliographic databases showed no publications on sleepwalking in non-human primates. From this finding, two inferences can be made. First is that somnambulism may be present in non-human primates; but due to(More)
The probable existence of a biochemical cycle, involving histamine, interleukins and prostaglandins for regulating sleep and wakefulness in higher vertebrates is proposed in this paper. For convenience, it is given an acronym, H-I-P cycle. The proposed biochemical cycle consists of 13 essential steps, with four regulatory points. How this cycle differs from(More)