Sachi Sri Kantha

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The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 microliter per min for 6 hr (2300-0500 hr) through chronically implanted microdialysis probes or infusion cannulae. Among the administrations of PDG2 by dialysis probes (n =(More)
L- Carnosine (beta-alanyl L-histidine), occurring abundantly in skeletal muscles, has been suggested to possess antioxidant and anti-aging properties. Using three different experimental approaches (microscopic, flow cytometric and ELISA for one of the markers of DNA oxidative damage) this study on rat embryonic fibroblasts demonstrates that L-carnosine at(More)
By his own admission, Albert Einstein, 'started to talk comparatively late ... certainly not younger than three', and also had 'poor memory of words', during his childhood years. If lesions in Brodmann Area 39 of the cerebral hemisphere results in dyslexia, the 1985 report on the study of Einstein's brain that the neuron:glial ratio of Area 39 in the left(More)
For the last 39 of his 76 years of life, physicist Albert Einstein (1879-1955) suffered from chronic illness. His health problems were primarily related to multiple complications of digestive system disorders; liver ailment, stomach ulcer, inflammation of gall bladder, jaundice and intestinal pains. Based on the published autobiographical records and(More)
The significance of the 1890 tetanus antitoxin paper by von Behring and Kitasato in the development of a new discipline, immunology, is reviewed. The possible reasons why Kitasato lost the first Nobel Prize for medicine to von Behring are presented. These are as follows: (1) The Nobel selection committee literally interpreted Alfred Nobel's will to award(More)
The scientific productivity of Albert Einstein was compared to that of designated controls Karl Landsteiner (an experimental scientist) and Sigmund Freud (an eminent theorist). Three assumptions made for this comparison were (1) that Einstein and his designated controls had equal scientific stature; (2) that their publications were produced in a similar, if(More)
Prostaglandin (PG) D2 has been postulated to be an endogenous sleep-promoting factor. Biosynthesis of PGD2 is catalyzed by PGD synthase (prostaglandin-H2 D-isomerase, EC, the activity of which is inhibited by inorganic selenium compounds such as SeCl4 and Na2SeO3. We recently examined the effect of intracerebroventricular administration of these(More)
Calreticulin (Crt) is a molecular chaperone ubiquitously present in the endoplasmic reticulum. In non-human primates, age-related occurrence of anti-Crt antibody has not been reported. We developed an ELISA assay for an anti-Crt antibody and determined the age-related increase in the levels of anti-Crt antibody in three groups of cynomolgus monkeys:(More)
Seasonal changes in the in vivo levels of the prostaglandins (PGs) PGD2, PGE2, and PGF2(alpha) were measured in the brain of the male Asian chipmunk, Tamias asiaticus (n = 111), which underwent hibernation during the period between November and March. The mean level of PGD2 ranged from 36.0 to 85.2 pg/g tissue from June to October and remained essentially(More)