Sachi Jayaram

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The depletion of dopamine levels in the brain due to degeneration of dopaminergic neurons of substantia nigra pars compacta is a hallmark of Parkinson's disease (PD). The cumulative contribution of genetic variations in genes from the dopaminergic pathway has been widely implicated to confer susceptibility to idiopathic PD. We present in this paper an(More)
Recent discovery of pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's disease (PD) patients in different ethnic groups have raised a hope of diagnostic screening and genetic counseling. We investigated the six most commonly reported mutations in LRRK2 gene among Indian PD patients, using PCR-RFLP method. Mutations G2019S,(More)
The endpoint included in the sectioned testes assay has been evaluated in other studies. However, the protocol itself has not been validated. Pending a final decision on the study design, the protocol would be ready to enter the prevalidation phase. Optimization of the assay could be determined for the amount of testis actually needed to obtain a given(More)
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