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Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14
Summary Bacterial populations differentiate at the subspecies level into clonal complexes. Intraclonal genome diversity was studied in 100 isolates of the two dominant P seudomonas aeruginosa clonesExpand
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No human virus sequences detected by next‐generation sequencing in benign verrucous skin tumors occurring in BRAF‐inhibitor‐treated patients
Patients treated with BRAF inhibitors (e.g. vemurafenib), a novel targeted therapy for advanced melanoma harbouring certain BRAF mutations, develop numerous adverse cutaneous side effects, includingExpand
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Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not beenExpand
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Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis
The mouse pathobiont Helicobacter hepaticus can induce typhlocolitis in interleukin-10-deficient mice, and H. hepaticus infection of immunodeficient mice is widely used as a model to study the roleExpand
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Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide
Objective Antimicrobial peptides (AMP) provide protection from infection by pathogenic microorganisms and restrict bacterial growth at epithelial surfaces to maintain mucosal homeostasis. InExpand
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BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection
Background Clostridium difficile infection (CDI) is a major cause of hospital-acquired diarrhea. Secondary bile acids were shown to confer resistance to colonization by C. difficile.Expand
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Microbiota-associated risk factors for C. difficile acquisition in hospitalized patients: A prospective, multicentric study.
BACKGROUND Asymptomatic C. difficile colonization is believed to predispose to subsequent C. difficile infection (CDI). While emerging insights into the role of the commensal microbiota in mediatingExpand
In Vivo Genome and Methylome Adaptation of cag-Negative Helicobacter pylori during Experimental Human Infection
Exceptional genetic diversity and variability are hallmarks of Helicobacter pylori, but the biological role of this plasticity remains incompletely understood. Here, we had the rare opportunity toExpand