Sabrina Schmitt

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Stability of many tumor-relevant proteins is partly mediated by E3 ligases, which determine substrate specificity within the ubiquitin system. Recent data demonstrated that increased nuclear expression of the E3 ligase seven in absentia homologue (SIAH)-1 in human hepatocarcinogenesis supports tumor cell proliferation and migration. To define whether(More)
BACKGROUND During extracorporeal photophoresis (ECP), peripheral blood mononuclear cells are treated with DNA-intercalating agents and irradiated with ultraviolet light. This procedure exerts immunosuppressive effects, most likely mediated by regulatory T cells (Treg). However, the underlying mechanisms are not clear yet. In our study, we investigated the(More)
Cutaneous regeneration utilizes paracrine feedback mechanisms to fine-tune the regulation of epidermal keratinocyte proliferation and migration. However, it is unknown how fibroblast-derived hepatocyte growth factor (HGF) affects these mutually exclusive processes in distinct cell populations. We here show that HGF stimulates the expression and(More)
Reduction of serum DNASE1 (DNase I) activity is supposed to aggravate anti-nuclear autoimmunity, i.e. Systemic Lupus Erythematosus (SLE) in man and mice. To evaluate the etiology of this reduction, more information is needed about the source(s) and regulation of serum DNASE1. In this work we used male C57BL/6 wild-type (WT) mice to verify that serum Dnase1(More)
Innerhalb der letzten Jahre wurden sowohl national als auch international zahlreiche Biobanken etabliert, die verschiedenste Kollektive humaner Biomaterialien und assoziierter phänotypischer Daten sammeln, aufbereiten und für Forschungszwecke zur Verfügung stellen. Vor dem Hintergrund der teilweise großen Heterogenität sowohl in der Struktur als auch in der(More)
The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification method. Conventional tablets containing theophylline as a model hydrophilic drug were prepared. The theophylline tablets(More)
Zur Förderung des Rauchausstiegs sind qualifizierte und differenzierte Angebote zur Raucherentwöhnung flächendeckend erforderlich. Zur Feststellung des aktuellen Stands und der Struktur der Therapieangebote wurde im Jahr 2007 eine (Voll-)Erhebung von Angeboten zur Tabakentwöhnung mit dem Ziel durchgeführt, Unterschiede zwischen den Anbietern und in der(More)
An effective means to analyze mRNA expression data is to take advantage of established knowledge from pathway databases, using methods such as pathway-enrichment analyses. However, pathway databases are not case-specific and expression data could be used to infer gene-regulation patterns in the context of specific pathways. In addition, canonical pathways(More)
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