Sabrina Rajan

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BACKGROUND The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating(More)
AIMS Traditionally, a core biopsy diagnosis of radial scar will prompt diagnostic surgery because of the risk of associated malignancy. However, in the absence of atypia, the risk of malignancy is low. The recent introduction of the mammotome device facilitates vacuum-assisted large-volume sampling of a lesion, such that a benign diagnosis may be accepted(More)
AIM To assess the clinical impact of a new patient management pathway incorporating vacuum-assisted biopsy for lesions of uncertain malignant potential (B3). MATERIALS AND METHODS A retrospective analysis was undertaken of all B3 lesions on core biopsy in the pathology database from April 2008 to April 2010. Outcome measures assessed included final(More)
AIMS To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy. METHODS A retrospective analysis was performed of all core biopsies containing FEA and/or atypical intraductal(More)
Cervical cancer is the most common cancer among women in South India. More than 70% of the cases present in stage IIB and IIIB and of these more than 50% fail conventional treatment. The purpose of the present study was to determine the prognostic significance of Bcl-2 and p53 expression in squamous cell carcinomas of the cervix. Using immunohistochemistry,(More)
Introduction: This multicentre randomised controlled trial investigated whether a computed tomography (CT) scan of the axilla could more accurately assess whether the axillary lymph nodes were involved with malignancy in patients with newly diagnosed breast cancer and therefore influence surgical decision-making with regard to axillary surgery. Methods:(More)
O1 Validation of a new automated volumetric breast density measurement system as a marker of breast cancer risk K Pinker1,2, N Perry2, S Milner2, K Mokbel2, S Duff y3 1Department of Radiology, Division of Molecular and Gender Imaging, Medical University Vienna, Austria; 2Princess Grace Hospital, The London Breast Institute, London, UK; 3Wolfson Institute,(More)
Introduction The low sensitivity of ultrasonography (US) in diagnosing axillary lymph node metastasis in breast cancer patients has sparked the evaluation of various tools in an attempt to increase pre-operative sensitivity. We compared axillary lymph node metastasis probability scores with post-surgical findings, using the Memorial Sloan Kettering Cancer(More)
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