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T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause… (More)
In human leukocyte antigen haplotype-mismatched transplantation, extensive T-cell depletion prevents graft-versus-host disease (GVHD) but delays immune recovery. Granulocyte colony-stimulating factor… (More)
BACKGROUND Allogeneic hematopoietic transplantation relies on T-cell alloreactions for engraftment and the GvL effect. In HLA haplotype-mismatched transplants, extensive T-cell depletion of the graft… (More)
In HLA haplotype-mismatched hematopoietic transplants (Aversa et al, NEJM 1998), when KIR epitope incompatibility is in the GvH direction, the post-grafting NK repertoire contains high-frequency… (More)