Sabrina L. Mitchell

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Smoking may enhance satiety following meal consumption, thereby reducing subsequent eating (i.e., between-meal snacks), especially in women high in dietary restraint. Female smokers (n = 20, 10 high and 10 low restraint) and male smokers (n = 10) participated in two sessions, involving overnight abstinence from food and smoking (smoking abstinence day) or(More)
Mitochondrial DNA (mtDNA) haplogroups are valuable for investigations in forensic science, molecular anthropology, and human genetics. In this study, we developed a custom panel of 61 mtDNA markers for high-throughput classification of European, African, and Native American/Asian mitochondrial haplogroup lineages. Using these mtDNA markers, we constructed a(More)
Stress has been shown to increase food consumption in women with high levels of dietary restraint (restrainers) but decrease consumption in nonrestrainers. The present study was designed to replicate the differential eating pattern following stress and measure physiological and subjective responses to food over repeated taste presentations. Restrained (N =(More)
Genome-wide association studies (GWAS) have identified ~100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and 18 GWAS loci on the Metabochip for their association with(More)
The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all(More)
The present study examined the effects of calories on salivary habituation. The rate of habituation to lemon taste was studied over 10 trials in 24 normal weight, nondieting, 18-35-year-old females. Between each of the trials, half the subjects ate low calorie, lemon gelatin, total Kcal = 32, and the others ate high calorie, lemon gelatin, total Kcal = 320.(More)
Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer(More)
Substantial progress has been made in identifying susceptibility variants for age-related macular degeneration (AMD). The majority of research to identify genetic variants associated with AMD has focused on nuclear genetic variation. While there is some evidence that mitochondrial genetic variation contributes to AMD susceptibility, to date, these studies(More)
Dietary restraint is a characteristic associated with greater increase in food intake after smoking cessation, and salivation is a marker of physiological responsiveness to food that may be influenced by cessation. The present study examined the effect of brief smoking abstinence (16 h) vs. no abstinence on salivary and subjective responses to food taste(More)
We have previously shown that salivation to the same food habituates, and recovers after presenting novel nontaste stimuli. This study assessed the effects of environmental stimuli that differentially influence subjective and autonomic arousal on dishabituation of salivation. Thirty female subjects were preloaded on a lemon yogurt milkshake and habituated(More)