Sabine Witte

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PURPOSE To evaluate the protein-binding and signal enhancement characteristics of MS-325, a gadolinium-based magnetic resonance (MR) imaging blood pool agent that binds to albumin, and compare results with those obtained with existing gadolinium- and iron oxide-based agents. MATERIALS AND METHODS Protein binding in human plasma was measured by means of(More)
PURPOSE To evaluate the imaging performance and patient tolerance of a blood-pool contrast agent (MS-325) for magnetic resonance (MR) angiography. MATERIALS AND METHODS Imaging of peripheral and carotid vessels was performed in seven healthy volunteers in a phase I clinical trial of the gadolinium chelate MS-325. Each volunteer received an intravenous(More)
UNLABELLED So far in Europe, no studies have been published on the structuring of medical care for obese children and adolescents. Besides anthropometric parameters, evaluations of the cardiovascular risk factors hypertension, dyslipidaemia, impaired glucose metabolism and treatment modalities were documented in a standardised multicentre evaluation survey(More)
Cell material obtained from 161 patients by gastroscopic aided brushing was compared cytologically and DNA flow cytometrically and evaluated by mathematical discriminant analysis. Whereas all but one of the cytologically confirmed malignant cases were also positive (malignant) in flow cytometry, the DNA determination failed in 6 of the 19 cytologically(More)
REASONS FOR PERFORMING STUDY The diagnosis of equine back disorders is challenging. Objectively determining movement of the vertebral column may therefore be of value in a clinical setting. OBJECTIVES To establish whether surface-mounted inertial measurement units (IMUs) can be used to establish normal values for range of motion (ROM) of the vertebral(More)
Gastric mucosa was obtained from 126 patients by endoscopic biopsy and subsequent cell brushing for histological, cytological and DNA cytophotometric studies. 23 cases were carcinomatous. DNA histogram evaluation for each case was carried out with special consideration of the position of the DNA stem line and the scatter of the measured DNA values.(More)
In two groups of ten patients each, an ionic and a nonionic contrast medium was injected intravenously, for digital subtraction angiography of the supra-aortic branches, to examine the influence of hemorrheologic properties. Afterward, blood samples were obtained through a central venous catheter and evaluated by a new instrument (oscillating capillary(More)
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