• Publications
  • Influence
Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*
Intracellular accumulation of insoluble α-synuclein in Lewy bodies is a key neuropathological trait of Parkinson disease (PD). Neither the normal function of α-synuclein nor the biochemicalExpand
  • 54
  • 2
  • PDF
Nestin-positive mesenchymal stem cells favour the astroglial lineage in neural progenitors and stem cells by releasing active BMP4
BackgroundSpontaneous repair is limited after CNS injury or degeneration because neurogenesis and axonal regrowth rarely occur in the adult brain. As a result, cell transplantation has raised muchExpand
  • 88
  • 1
  • PDF
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors
BackgroundAlpha-Synuclein (α-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutationsExpand
  • 28
  • 1
  • PDF
Regulation of nestin expression by thrombin and cell density in cultures of bone mesenchymal stem cells and radial glial cells
BackgroundBone marrow stromal cells and radial glia are two stem cell types with neural phenotypic plasticity. Bone marrow mesenchymal stem cells can differentiate into osteocytes, chondrocytes andExpand
  • 20
  • PDF
Regulation of α-synuclein compartmentalization by rab3a and GDI
O3-G2-5 Genetic inactivation of the habenulo-interpeduncular projection enhances the conditioned fear response in zebrafish Masakazu Agetsuma1, Hidenori Aizawa1, Tazu Aoki1, Mikako Takahoko1, RyokoExpand
8 Regulation of-Synuclein Membrane Binding and Its Implications
1.1 Parkinson’s disease and Lewy bodies Parkinson’s disease (PD) is the most prevalent neurodegenerative disease that affects motor control, although dementia, depression, and other psychiatricExpand