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Even though decision-making in small teams is pervasive in business and in private life, little is known about subjects' preferences with respect to individual and team decision-making and about the consequences of respecting these preferences. We report the results from an experimental beauty-contest game, where subjects could endogenously choose their(More)
Harman occurs in rat brain, with the highest concentration in the cerebellum and the lowest in the striatum. 2 g/kg ethanol were ineffective with respect to the concentration of harman in the brain whereas 5 g/kg ethanol caused a time-dependent increase in the cerebral cortex as well as the cerebellum. A toxic dose (8 g/kg) of ethanol elicited no change of(More)
After injection of 20 mg/kg of the monoamine oxidase inhibitor pargyline every other day up to 9 days, the activity of N-acetyltransferase (NAT) in the pineal gland of rats remained unchanged during the light-period. At the darkness, however, an increase above controls was observed. The latter effect was not affected by subchronic administration. The(More)
The distribution, metabolism and elimination into the urine of (14C)-tetrahydronorharmane (THN) as well as of (14C)-6-hydroxy-tetrahydronorharmane (6-OH-THN) are investigated in female and male rats. Following intravenous injection of (14C)-THN radioactivity was detected in all organs examined, namely blood, brain, lung, adrenal gland, small intestine, fat(More)
The dorsal raphe nucleus (DRN), the median raphe nucleus (MRN) and the B9 cell groups were lesioned separately. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA), 5-hydroxytryptophan (5-HTP) and dopa were measured in various brain regions. The levels of the two latter compounds presumably reflect the(More)
The in vitro binding of the naturally occurring β-carbolines harman and norharman in their tritium-labelled forms to cell membranes from the rat brain and liver and from bovine adrenal medulla was investigated. Displacement of the specific [3H]harman binding in bovine adrenal medulla and rat liver by several β-carbolines and monoamine oxidase (MAO)(More)
Injection of tetrahydronorharmane (THN) elicited a dose-dependent increase of the level of 5-hydroxytryptamine (5-HT) and a fall of 5-hydroxyindoleacetic acid in the rat brain whereas noradrenaline and dopamine levels remained unchanged. The effect on indoles was shortlasting which may be explained by the short half life of THN or its metabolization to(More)
8078 Background: MOR202, a HuCAL-derived fully human anti-CD38 antibody mediates ADCC of multiple myeloma (MM) patient cells with high potency (EC50 ~200 pM) and represents a promising new therapy for MM patients. Bortezomib (BOR), a proteasome inhibitor, and lenalidomide (LEN), an immunomodulatory agent, two commonly used agents in MM therapy were(More)
Apomorphine-induced stereotypic behavior was investigated in rats treated with diazepam or haloperidol and with the combination of both drugs in a one day trial or subchronically. The drugs were administered via the drinking water. Diazepam dose-dependently reduced apomorphine stereotypies after the subchronic (6 days) but not after the acute treatment.(More)