Sabine Schumacher

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The FGF receptor Heartless (HTL) is required for mesodermal cell migration in the Drosophila gastrula. We show that mesoderm cells undergo different phases of specific cell shape changes during mesoderm migration. During the migratory phase, the cells adhere to the basal surface of the ectoderm and exhibit extensive protrusive activity. HTL is required for(More)
The role of the epithelial cell adhesion molecule EpCAM in cancer progression remains largely unclear. High expression of EpCAM in primary tumors is often associated with more aggressive phenotypes and EpCAM is the prime epithelial antigen in use to isolate circulating tumor cells (CTCs) and characterize disseminated tumor cells (DTCs). However, reduced(More)
OBJECTIVE There is growing evidence of premature atherosclerosis in patients with rheumatoid arthritis (RA), leading to a higher rate of cardiovascular events than in the general population. The augmentation index (AIx), a marker of arterial stiffness, is an indicator of vascular function. The aim of the study was as follows: (1) to investigate whether AIx(More)
In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the role of the evolutionary conserved(More)
The Drosophila guanine nucleotide exchange factor Pebble (Pbl) is essential for cytokinesis and cell migration during gastrulation. In dividing cells, Pbl promotes Rho1 activation at the cell cortex, leading to formation of the contractile actin-myosin ring. The role of Pbl in fibroblast growth factor-triggered mesoderm spreading during gastrulation is less(More)
Assessing the long-term dynamics of mountain landscapes that are influenced by large-scale natural and anthropogenic disturbances and a changing climate is a complex subject. In this study, a landscape-level ecological model was modified to this end. We describe the structure and evaluation of the fire sub-model of the new landscape model LandClim, which(More)
13. Lianos EA, Andres GA, Dunn MJ. Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. J Clin Invest 1983; 72: 1439–1448 14. Kwag OG, Kim SO, Choi JH et al. Vitamin E improves microsomal phospholipase A2 activity and the arachidonic acid cascade in kidney of diabetic rats. J Nutr 2001; 131: 1297–1301 15. Rubin C, Nolin TD,(More)
INTRODUCTION Gastrulation represents the first major morphogenetic event in the development of most multicellular animals. One key aspect of gastrulation is the specification of the presumptive mesoderm cells and their morphogenetic rearrangements within the embryo by dramatic cell movements. In Drosophila, these mesoderm movements can be divided into two(More)
Relapsing polychondritis (RPC) is a rare disease with recurrent episodes of inflammation of cartilage tissue leading to fibrosis and organ damage. Despite unknown etiology, there is some evidence of a genetic predisposition. The clinical presentation is heterogeneous and an association with other autoimmune disorders such as rheumatoid arthritis or(More)
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