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INTRODUCTION Gastrulation represents the first major morphogenetic event in the development of most multicellular animals. One key aspect of gastrulation is the specification of the presumptive mesoderm cells and their morphogenetic rearrangements within the embryo by dramatic cell movements. In Drosophila, these mesoderm movements can be divided into two(More)
In mammalian cells, DNA double-strand breaks (DSBs) are repaired by three pathways, nonhomologous end-joining (NHEJ), gene conversion (GC) and single-strand annealing (SSA). These pathways are distinct with regard to repair efficiency and mutagenic potential and must be tightly controlled to preserve viability and genomic stability. Here, we employed(More)
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