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Does plasticity contribute to adult cognitive development, and if so, in what ways? The vague and overused concept of plasticity makes these controversial questions difficult to answer. In this article, we refine the notion of adult cognitive plasticity and sharpen its conceptual distinctiveness. According to our framework, adult cognitive plasticity is(More)
Effects of cognitive activities on walking variability are poorly understood. We parametrically manipulated working-memory load by using an n-back task in 32 younger adults and 32 older adults walking on a treadmill at self-selected speed. We found no dual-task costs for cognitive performance. Stride-to-stride variability was lower when participants(More)
Benzylsuccinate synthase (Bss) is the key enzyme of anaerobic toluene degradation and has been found in all anaerobic toluene degrading bacterial isolates tested. However, only a few pure cultures capable of anaerobic toluene oxidation are available to date, and it is important to understand the relevance of these model organisms for in situ bioremediation(More)
We investigated effects of concurrent cognitive task difficulty (n-back) on the regularity of whole-body movements during treadmill walking in women and men from 3 age groups (20-30, 60-70, and 70-80 years old). Using principal component analysis of individual gait patterns, we separated main (regular) from residual (irregular) components of whole-body(More)
Recent evidence indicates experience-dependent brain volume changes in humans, but the functional and histological nature of such changes is unknown. Here, we report that adult men performing a cognitively demanding spatial navigation task every other day over 4 months display increases in hippocampal N-acetylaspartate (NAA) as measured with magnetic(More)
This study investigates the effects of fitness changes on hippocampal microstructure and hippocampal volume. Fifty-two healthy participants aged 59-74years with a sedentary lifestyle were randomly assigned to either of two levels of exercise intensity. Training lasted for six months. Physical fitness, hippocampal volumes, and hippocampal microstructure were(More)
It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related(More)
A widespread network involving cortical and subcortical brain structures forms the neural substrate of human spatial navigation. Most studies investigating plasticity of this network have focused on the hippocampus. Here, we investigate age differences in cortical thickness changes evoked by four months of spatial navigation training in 91 men aged 20-30 or(More)
Histopathological alterations in the reproductive tissue of the female sea urchin Psammechinus miliaris after exposure to the polycyclic aromatic hydrocarbon (PAH) phenanthrene were investigated using light microscopy. Sexually mature sea urchins were exposed to 500 microg L(-1) phenanthrene for 20 days. A severe disorganisation of the acinal structure of(More)
We investigated dual-task performance of cognitive (semantic fluency) and sensorimotor tasks (walking) in 120 children and adults from four age groups (9-year olds, M=9.52 years; 11-year olds, M=11.51 years; young adults, M=25.34 years; older adults, M=64.28 years; N=30 per group). Distances walked during 90 s and numbers of category exemplars generated in(More)