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Nerve growth factor signal transduction in mature pig oligodendrocytes.

• Holger Althaus, R. Hempel, +4 authors Rolf Heumann
• Journal of neuroscience research
• 1997

It has previously been shown that nerve growth factor (NGF) is of functional significance for mature pig oligodendrocytes (OLs) in culture. The present data give evidence for the expression of TrkA,… (More)

Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation.

• Holger Althaus, Jenny Schröter, +4 authors Volker Neuhoff
• Journal of neuroscience research
• 1991

Oligodendrocytes (OL) isolated from adult pig brains regenerate their processes and form a network of fibers after 14-18 days in vitro (DIV). Stimulation of protein kinase C (Pk-C) by tumour… (More)

Nerve growth factor induces proliferation and enhances fiber regeneration in oligodendrocytes isolated from adult pig brain.

• Holger Althaus, Sabine Klöppner, Tyede H. Schmidt-Schultz, P. Schwartz
• Neuroscience letters
• 1992

Mature oligodendrocytes (OL) isolated from adult pig brains start to regenerate their fibers after 4-5 days in vitro (DIV); after 14 DIV a network of OL fibers is formed. Growth factors, of which it… (More)

Differential response of mature TrkA/p75(NTR) expressing human and pig oligodendrocytes: aging, does it matter?

• Holger Althaus, Kay Mursch, Sabine Klöppner
• Microscopy research and technique
• 2001

A differential morphological response of mature oligodendrocytes (OL) isolated from human and pig brains to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and to the nerve growth factor… (More)

Oligodendroglial Cells and Neurotrophins: A Polyphonic Cantata in Major and Minor

• Hans H. Althaus, Sabine Klöppner, Steve Klopfleisch, Matthias Schmitz
• Journal of Molecular Neuroscience
• 2008

Oligodendrocytes met neurotrophins in the early 1990s of the last century. Since then, their relationship underwent functional ups and downs partially dependent on the developmental stage of the… (More)

Mature pig oligodendrocytes rapidly process human recombinant pro-nerve growth factor and do not undergo cell death.

• Hans H. Althaus, Sabine Klöppner
• Journal of neurochemistry
• 2006

The neurotrophin family with its first member, nerve growth factor (NGF), binds two classes of receptors, more specifically to Trk receptors and to a shared p75NTR receptor. It has been shown that… (More)

Myelin basic protein induces cell death of mature pig oligodendrocytes in vitro and produces demyelination in vivo.

• Holger Althaus, Sabine Klöppner, +4 authors W J Holtz
• Neuroscience letters
• 2000

Two methods prevail at present in producing demyelinated areas in the central nervous system. One uses the detergent-like effect of lysolecithin, the other is based on a cell killing effect of… (More)

Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo.

• Steve Klopfleisch, Doron Merkler, +5 authors Wolfgang Brück
• The Journal of neuroscience : the official…
• 2008

Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small… (More)

Mutual effects of caveolin and nerve growth factor signaling in pig oligodendrocytes.

• Matthias Schmitz, Sabine Klöppner, +4 authors Hans H. Althaus
• Journal of neuroscience research
• 2010

Signaling of growth factors may depend on the recruitment of their receptors to specialized microdomains. Previous reports on PC12 cells indicated an interaction of raft-organized caveolin and TrkA… (More)

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