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For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on estimation of gene expression signals for homogeneous cell populations, e.g. by applying micro-dissection, fluorescence activated cell sorting, or in-silico deconfounding. We studied feasibility(More)
Five experiments present the first piece of evidence from online processing (self-paced reading and eyetracking) that omitting the middle verb in a double center embedding yields an illusion of grammaticality in English, but not in German. One commonly accepted explanation for the English illusion – based on data from offline acceptability ratings – is the(More)
through Yale University from the Blue Cross Blue Shield Association to better understand medical technology evaluation, from the Laura and John Arnold Foundation to better understand clinical research integrity and transparency, and from the U.S. Food and Drug Administration to develop methods for postmarketing surveillance of medical devices. All other(More)
PURPOSE High-density lipoproteins (HDL) have long been implicated in the pathogenesis of age-related macular degeneration (AMD). However, conflicting results have been reported with regard to the associations of AMD with HDL-cholesterol levels. The present study is the first to assess HDL composition and metrics of HDL function in patients with exudative(More)
Proteomics have extended the list of high-density lipoprotein (HDL) associated proteins to about 90. One of the major issues of global protein characterization is establishing specificity of association as opposed to contamination, a fact which has never been addressed for isolated HDL. We have developed a refined purification strategy to isolate HDL by(More)
Context Obesity is associated with hypoadiponectemia, dyslipidemia and increased risk of coronary vascular disease (CVD). Mechanisms linking these conditions remain to be fully understood. Cholesterol efflux capacity (CEC) is a crucial functional property of high-density lipoprotein (HDL) that strongly predicts CVD incidence. Objective To investigate(More)
Analysis of structural and functional parameters of HDL have gained significant momentum in recent years since they are stronger predictors of cardiovascular risk than HDL-cholesterol levels. Surprisingly, in most HDL studies very low attention is paid to HDL storage, which might critically affect functional properties. In the present study, we(More)
BACKGROUND Pharmacologic pre- and postconditioning with sevoflurane compared with total IV anesthesia in patients undergoing liver surgery reduced complication rates as shown in 2 recent randomized controlled trials. However, the potential health economic consequences of these different anesthesia regimens have not yet been assessed. METHODS An expostcost(More)
Figs 1 and 2 are incorrectly duplicated from Figs 3–4. The authors have provided corrected versions here. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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