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Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes
Background Exosomes are small membranous vesicles secreted into body fluids by multiple cell types, including tumor cells, and in various disease conditions. Tumor exosomes contain intact and… Expand
MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation
Macrophage migration inhibitory factor (MIF) is produced by monocytes in cancer-bearing mice and humans. MIF was found to be critical for suppressive monocytic cells in melanoma patients, and when… Expand
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
- R. Singh, Sandeep Chandrashekharappa, +18 authors V. Jala
- Chemistry, Medicine
- Nature Communications
- 9 January 2019
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease… Expand
Ubiquilin1 Represses Migration and Epithelial to Mesenchymal Transition of Human Non-small Cell Lung Cancer Cells
Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during… Expand
Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l.
Embryonic stem cell (ESC) abnormalities in genome methylation hamper the utility of their therapeutic derivatives; however, the underlying mechanisms are unknown. Here, we show that the nicotinamide… Expand
Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development.
It is clear that obesity increases the risk of many types of cancer, including breast cancer. However, the underlying molecular mechanisms by which obesity is linked to cancer risk remain to be… Expand
Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state.
Recently, we identified a population of Oct4(+)Sca-1(+)Lin(-)CD45(-) very small embryonic-like stem cells (VSELs) in murine and human adult tissues. VSELs can differentiate in vitro into cells from… Expand
MIF inhibition reverts the gene expression profile of human melanoma cell line-induced MDSCs to normal monocytes
- Sabine J. Waigel, B. Rendon, Gwyneth J. Lamont, Jamaal Richie, R. Mitchell, K. Yaddanapudi
- Biology, Medicine
- Genomics data
- 9 January 2016
Myeloid-derived suppressor cells (MDSCs) are potently immunosuppressive innate immune cells that accumulate in advanced cancer patients and actively inhibit anti-tumor T lymphocyte responses .… Expand
Cell cycle pathway dysregulation in human keratinocytes during chronic exposure to low arsenite
- Laila Al-Eryani, Sabine J. Waigel, V. Jala, Samantha F Jenkins, Christopher J. States
- Biology, Medicine
- Toxicology and applied pharmacology
- 15 September 2017
Background: Arsenic is naturally prevalent in the earth's crust and widely distributed in air and water. Chronic low arsenic exposure is associated with several cancers in vivo, including skin… Expand
Transcriptional profile of immediate response to ionizing radiation exposure
Astronauts participating in long duration space missions are likely to be exposed to ionizing radiation associated with highly energetic and charged heavy particles. Previously proposed gene… Expand