Sabine Grosser

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miR-128, a brain-enriched microRNA, has been implicated in the control of neurogenesis and synaptogenesis but its potential roles in intervening processes have not been addressed. We show that post-transcriptional mechanisms restrict miR-128 accumulation to post-mitotic neurons during mouse corticogenesis and in adult stem cell niches. Whereas premature(More)
Epilepsy is a disorder characterized by excessive synchronized neural activity. The hippocampus and surrounding temporal lobe structures appear particularly sensitive to epileptiform activity. Somatostatin (SST)-positive interneurons within the hilar region have been suggested to gate hippocampal activity, and therefore may play a crucial role in the(More)
Norepinephrine acting via β-adrenergic receptors (β-ARs) plays an important role in hippocampal plasticity including the subiculum which is the principal target of CA1 pyramidal cells and which controls information transfer from the hippocampus to other brain regions including the neighboring presubiculum and the entorhinal cortex (EC). Subicular pyramidal(More)
20 miR-128, a brain-enriched microRNA, has been implicated in the control of 21 neurogenesis and synaptogenesis but its potential roles in intervening processes 22 have not been addressed. We show that post-transcriptional mechanisms restrict 23 miR-128 accumulation to post-mitotic neurons during mouse corticogenesis and in 24 adult stem cell niches.(More)
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