Sabine Goetz

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The discoidin domain receptor (DDR1) is characterized by a discoidin I motif in the extracellular domain, an unusually long cytoplasmic juxtamembrane (JM) region, and a kinase domain that is 45% identical to that of the NGF receptor, TrkA. DDR1 also has a major splice form, which has a 37 amino acid insert in the JM region with a consensus Shc PTB site that(More)
In the Atlantic, economic losses have been reported from shark, swordfish and tuna longline fisheries due to depredation by cetaceans. We examined interactions of odontocete cetaceans with commercial longliners operating in waters off Brazil and the Azores archipelago during 2006–2007, analysing relationships between catches, depredation on hooked fish,(More)
Acoustic deterrent devices (pingers) that are designed to alert marine mammals to the presence of fishing gear have been successfully employed to reduce cetacean–fishery interactions. However, pinger sounds may affect fisheries target species: noise can induce short-term stress responses in fish that are reflected in increased blood cortisol concentrations(More)
Bardet-Biedl syndrome (BBS) and Meckel-Gruber syndrome (MKS) are genetic disorders caused by disruption of primary cilia. The BBS and MKS proteins are found in two distinct protein complexes but the functional relationships between these two complexes are not clear. Here we analyze double mutant mouse embryos to define these relationships. Bbs4;Mks1 double(More)
Despite the critical importance of cilia in development and disease, the biochemical pathways that initiate ciliogenesis at the mother centriole are not well understood. Here we describe the identification of a serine-threonine protein kinase, Ttbk2, as an essential component of the ciliary initiation pathway. The mouse mutant bartleby (bby) was isolated in(More)
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