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Anti (alpha)-DEC-205 antibodies target to the DEC-205 receptor that mediates antigen presentation to T cells by dendritic cells. To exploit these properties for immunization purposes, we conjugated the melanoma antigen tyrosinase-related protein (TRP)-2 to alphaDEC-205 antibodies and immunized mice with these conjugates together with dendritic(More)
Naturally occurring CD4 + CD25 Tregs (nTregs) are essential for T cell homeostasis and the maintenance of peripheral tolerance. They prevent the activation of autoaggressive T cells in the context of autoimmune diseases and suppress inadequate allergen specific T cells. On the opposite, nTregs inhibit also effective immune responses against tumors such as(More)
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