Sabine Broesel

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Heart and vascular endothelial cells from human pluripotent stem cells are of interest for applications in cell therapy and cardiovascular disease. Differentiation protocols are now sufficiently refined that production of cardiomyocytes, endothelial-and smooth muscle cells is fairly efficient and reproducible. Genetically marked hESCs have been produced in(More)
OBJECTIVE In vitro endothelialization has significantly improved the overall outcome of artificial prostheses in cardiovascular bypass surgery. A drawback of this tissue-engineering method remains the limited availability of suitable autologous endothelial cells (EC), especially in aged patients. Allogeneic EC with high proliferative capacity represent a(More)
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