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β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

• Sarah Jayne Creed, Caroline P. Le, +11 authors Erica K. Sloan
• Breast Cancer Research
• 2015

For efficient metastatic dissemination, tumor cells form invadopodia to degrade and move through three-dimensional extracellular matrix. However, little is known about the conditions that favor… (More)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

• Magdalena Korczynska, Mary Clark, +15 authors Roger K Sunahara
• Proceedings of the National Academy of Sciences…
• 2018

Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site. However, allosteric sites of these… (More)

Structure-Based Design and Discovery of New M2 Receptor Agonists.

• Inbar Fish, Anne Stössel, +9 authors Peter Gmeiner
• Journal of medicinal chemistry
• 2017

Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related center. On the basis of the active state… (More)

"Selective" Class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands.

• Shane D Hellyer, Sabine Albold, +4 authors Karen J. Gregory
• Molecular pharmacology
• 2018

Numerous positive and negative allosteric modulators (PAMs and NAMs) of Class C G protein-coupled receptors (GPCRs) have been developed as valuable preclinical pharmacological tools and therapeutic… (More)

β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer

• Aeson Chang, Caroline P. Le, +9 authors Erica K. Sloan
• Brain, Behavior, and Immunity
• 2016

Chronic stress accelerates metastasis - the main cause of death in cancer patients - through the activation of β-adrenoceptors (βARs). We have previously shown that β2AR signaling in MDA-MB-231(HM)… (More)

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