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BACKGROUND Among marginal zone lymphomas (MZLs), bone marrow (BM) involvement features are well established in the splenic marginal zone lymphoma (SMZL); few data are available for extranodal marginal zone lymphoma (EMZL) and nodal marginal zone lymphoma (NMZL). PATIENTS AND METHODS Incidence and patterns of histologic BM involvement are studied in 120(More)
Exposure of the immature brain to general anesthesia is common. The safety of this practice has recently been challenged in view of evidence that general anesthetics can damage developing mammalian neurons. Initial reports on immature rats raised criticism regarding the possibly unique vulnerability of this species, short duration of their brain development(More)
Rapidly accumulating evidence indicates that clinically used general anesthesia causes massive, widespread neuroapoptotic degeneration in the developing mammalian brain. Susceptibility to anesthesia-induced neurotoxicity has been documented in rats, mice, guinea pigs, primates, and in this study, piglets; in short, anesthesia-induced developmental(More)
Attempts have been made by a number of methods to eliminate minimal residual disease from bone marrow to be reinfused in autologous transplantation. In this paper we describe a conjugate containing a monoclonal antibody, named 8A, recognising a plasma cell-associated antigen, and momordin, a ribosome-inactivating protein similar to the ricin A-chain. This(More)
BACKGROUND Patients with adult respiratory distress syndrome (ARDS) and acute lung injury (ALI) have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid. No information is available on their turnover. OBJECTIVES To analyze disaturated-phosphatidylcholine and surfactant protein-B turnover in(More)
As a source of peripherally available vasoactive agents, platelets may play a role in many cardiovascular events. This study aimed to assess the functional role of serotonin released by platelets in mediating the effects of sympathetic stimulation on vascular tone in healthy subjects. Platelet serotonin (5-HT) content and plasma catecholamine concentrations(More)
Rat pups were treated with the competitive NMDA antagonist CGP 39551 with daily injections on postnatal days 1 to 8. Cultures of cerebellar granule cells were prepared from these pups as well as from control pups of the same age and body weight. Granule neurons explanted from CGP 39551-treated pups showed a decreased survival, both at short (2 days) or(More)
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