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It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance… Continue Reading
Coeliac disease is an autoimmune disease characterized by inflammation localized to the small bowel, but less is known about systemic signs of inflammation. The aim was to measure cytokines of the T… Continue Reading
PROBLEM Increased levels of serum cytokines in early pregnancy may increase the risk of type 1 diabetes in the offspring. METHOD OF STUDY Early-pregnancy (between 10 and 16 gestational weeks) serum… Continue Reading
Islet autoantibodies are currently used to classify type 1 diabetes at diagnosis as they reflect the autoimmune pathogenesis of the disease. The presence of maternal autoantibodies reactive with… Continue Reading
The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the… Continue Reading
Objective The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure… Continue Reading