Sabina Anik

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The extreme vertexes design was shown to be an efficient method for the study of mixture problems, for generating points in the factor space that define a region for response surface analysis. By using this method, the solubility of butoconazole nitrate, an imidazole antifungal agent, was studied as a function of four components, polyethylene glycol 400,(More)
Streptococcal collagen-like protein 1 (Scl-1) is one of the most highly expressed proteins in the invasive M1T1 serotype group A Streptococcus (GAS), a globally disseminated clone associated with higher risk of severe invasive infections. Previous studies using recombinant Scl-1 protein suggested a role in cell attachment and binding and inhibition of serum(More)
Nafarelin, a potent gonadotropin-releasing hormone (GnRH) agonist, was absorbed rapidly into systemic circulation (time to reach peak concentration, 20 to 40 minutes) after intranasal but not after sublingual or vaginal administration. Serum elimination half-life was about 2 hours. Nasal absorption of nafarelin was increased by increasing the concentration(More)
Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys. Absorption was rapid and very reproducible, with peak levels occurring at 15-30 min and a bioavailability of approximately 2% relative to a subcutaneous dose. The nasal dose response was highly(More)
The molecular topological indexes proposed by Wiener (Wiener number), Hosoya (Z-value), and Randic (branching index) were corelated with computed molecular surface areas and aqueous solubilities for the monofunctional aliphatic alcohols, ethers, ketones, aldehydes, carboxylic acids, esters, and hydrocarbons. Comparison of the indexes with molecular surface(More)
Staphylococcus aureus infections present an enormous global health concern complicated by an alarming increase in antibiotic resistance. S. aureus is among the few bacterial species that express nitric-oxide synthase (bNOS) and thus can catalyze NO production from L-arginine. Here we generate an isogenic bNOS-deficient mutant in the epidemic(More)
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