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Synaptic vesicle tethering and the CaV2.2 distal C-terminal
Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or “tether” (Stanley, 1993). Recent studies haveExpand
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Characterization of a Synaptic Vesicle Binding Motif on the Distal CaV2.2 Channel C-terminal
Neurotransmitter is released from synaptic vesicles (SVs) that are gated to fuse with the presynaptic membrane by calcium ions that enter through voltage-gated calcium channels (CaVs). There isExpand
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The Calcium Channel C-Terminal and Synaptic Vesicle Tethering: Analysis by Immuno-Nanogold Localization
At chemical synapses the incoming action potential triggers the influx of Ca2+ through voltage-sensitive calcium channels (CaVs, typically CaV2.1 and 2.2) and the ions binds to sensors associatedExpand
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Molecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal
Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 andExpand
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Long C terminal splice variant CaV2.2 identified in presynaptic membrane by mass spectrometric analysis
CaV2.2 voltage-gated calcium channels play a key role in the gating of transmitter release at presynaptic terminals. Recently we used mass spectrometry (MS) to analyze the protein complex associatedExpand
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PDLIM5 is not a neuronal CaV2.2 adaptor protein
To the editor: PDLIM5 (postsynaptic density protein–95, discs-large, ZO1, Lin11–Isl-1–Mec-3), formerly known as enigma homolog (ENH) is a ~63-kDa cytoplasmic protein composed of a PDZ domain at the NExpand
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Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain
Summary Calcium entry through CaV2.2 calcium channels clustered at the active zone (AZ) of the presynaptic nerve terminal gates synaptic vesicle (SV) fusion and the discharge of neurotransmitters,Expand
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The Role of Cav2.2 C-Terminus in Calcium Channel Anchoring at the Presynaptic Transmitter Release Sites
Voltage gated neuronal calcium channels (Cav2.2) gate neurotransmitter release at specialized regions within the presynaptic nerve terminals, known as transmitter release sites (TRS). PublishedExpand