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Recent studies have suggested that non-fibrillar soluble forms of Abeta peptides possess neurotoxic properties and may therefore play a role in the molecular pathogenesis of Alzheimer's disease. We have identified solution conditions under which two types of soluble oligomers of Abeta40 could be trapped and stabilized for an extended period of time. The(More)
Protein S is a calcium-binding protein comprising two Greek key beta-barrel domains. We have used NMR and optical spectroscopies to show that, in the absence of calcium, the N-terminal domain of protein S forms two equilibrium folding intermediates that are in slow exchange. The intermediates arise from differential calcium-dependent folding of subdomains(More)
Since extra chromosomal material in humans was first described by Lejeune, Turpin, and Gautier (1959) in association with Down's syndrome, patients with trisomic and partial monosomic conditions have been studied in an attempt to locate specific genetic loci upon specific chromosomes. An individual with a deletion of part of an autosome is hemizygous for(More)
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